2010 Season Schedule
| Week | Date | Matchup | Time (CT) | TV |
| Preseason Wk 1 | TBA | at Seahawks | TBA | WKRN |
| Preseason Wk 2 | Mon. Aug. 23 | CARDINALS | 7:00 PM | ESPN |
| Preseason Wk 3 | TBA | at Panthers | TBA | WKRN |
| Preseason Wk 4 | TBA | at Saints | TBA | WKRN |
| - | - | - | - | - |
| Week 1 | Sun. Sep. 12 | RAIDERS | Noon | CBS |
| Week 2 | Sun. Sep. 19 | STEELERS | Noon | CBS |
| Week 3 | Sun. Sep. 26 | at Giants | Noon | CBS |
| Week 4 | Sun. Oct. 3 | BRONCOS | Noon | CBS |
| Week 5 | Sun. Oct. 10 | at Cowboys |
3:15 PM | CBS |
| Week 6 | Mon. Oct. 18 | at Jaguars | 7:30 PM | ESPN |
| Week 7 | Sun. Oct. 24 | EAGLES | Noon | FOX |
| Week 8 | Sun. Oct. 31 | at Chargers |
3:05 PM | CBS |
| Week 9 | Sun. Nov. 7 | BYE | ||
| Week 10 | Sun. Nov. 14 | at Dolphins |
Noon | CBS |
| Week 11 | Sun. Nov. 21 | REDSKINS | Noon | FOX |
| Week 12 | Sun. Nov. 28 | at Texans | Noon | CBS |
| Week 13 | Sun. Dec. 5 | JAGUARS | Noon | CBS |
| Week 14 | Thu. Dec. 9 | COLTS | 7:20 PM | NFLN |
| Week 15 | Sun. Dec. 19 | TEXANS | Noon | CBS |
| Week 16 | Sun. Dec. 26 | at Chiefs | Noon | CBS |
| Week 17 | Sun. Jan. 2 | at Colts | Noon | CBS |
*Due to flexible scheduling, the kickoff time of games in the latter part of the season are subject to change
